Approximately 50%, 30% and 20% of the contacts respectively had negative (0–4 mm), positive (5–14 mm) and strongly positive (15+ mm) Mantoux responses. Se injectează intradermic 0,1 ml suspensie de vaccin BCG astfel: – Pielea se prinde între degetul mare şi arătător. Attribuer une réponse Mantoux ‘positive’ à la vaccination BCG antérieure pourrait encourager à tort une impression d'immunité chez des contacts récemment exposés à des tuberculeux contagieux. Risque attribuable au vaccin. Vaccinul se administreaza strict intradermic, în partea postero-externă a braţului stâng, în treimea medie. 54 – n. 78 (29 September 1963) Torino da pagina 2808, Malossi C. - Innocuità, praticità ed utilità del VDS – in Minerva Medica (rivista) n. 30 -1959 –Torino -p 1068, Gaetano Salvioli in Minerva Medica (rivista) n. 30 – 1959 –Torino- p. 1066, Atti 2^ conferenza on antituberculare vaccinazioni con VDS (edito da GP Salvioli) 1970 – Bologna, Minerva Medica – n.30 – 1959 Torino – Atti convegno decennale sulla vaccinazione antitubercolare con il metodo italiano dedicato al VDS -Bologna 6 dicembre 1958 –pp 1063–1120, Ferro Alessandro – Taronna Sandro (1950) – Esperimento involontario sulla resistenza di bambini vaccinati (VPS) e non vaccinati contro la tbc di fronte a contagio altamente infettante: Nota 1ª– Notizie sull’episodio di Dolo a carattere perfettamente sperimentale e sulla mortalità dei due gruppi -in La Clinica Pediatrica Bologna – anno 32 – fasc.n 5 –1950 – pp 225 – 263, Marino Golinelli (San Felice sul Panaro, 11 October 1920) is an Italian entrepreneur and philanthropist, founder of the company Alfa Farmaceutici, then Alfa Wassermann, then, Renato Vecchiato – una cicatrice collettiva – Roma 2016, https://en.wikipedia.org/w/index.php?title=Salvioli%27s_diffusing_vaccine&oldid=980777721, Articles containing Italian-language text, Creative Commons Attribution-ShareAlike License, This page was last edited on 28 September 2020, at 11:37. Objective: To determine the influence of past BCG vaccination on tuberculin sensitivity in tuberculosis contacts. The VDS consisted of Mycobacterium tuberculosis (or Koch's bacilli), killed by heat and added to ferment hyaluronidase. Design: Prospective cohort study of tuberculin sensitivity using the Mantoux technique (5 TU). The VDS was also applied abroad: in Osaka in Japan, Czechoslovakia, Poland, Kolwezi (now in the Democratic Republic of Congo). La presencia de cicatriz BCG no parecía tener una influencia significativa sobre el grado de sensibilidad a la tuberculina. The plague took several months to heal. După un interval de 8-10 săptămâni de la vaccinare se instalează alergia vaccinală. Salvioli's diffusing vaccine (known by its Italian initials VDS, for vaccino diffondente Salvioli) was an Italian vaccine against tuberculosis used from 1948 until 1976, formulated by professor Gaetano Salvioli (1894–1982) of the University of Bologna. Vaccinarea BCG (Bacillus Calmette Guerin) este o vaccinare obligatorie în România, utilizată pentru imunizarea specifică împotriva tuberculozei.. Le degré de sensibilité tuberculinique augmentait à partir de l'âge de 20 ans et diminuait à partir de l'âge de 60 ans. Reacţiile adverse post-vaccinale pot include: Pentru verificarea cunoștințelor, rezolvă testele din secțiunea Teste grilă. Resultados: En el 76% de 1050 contactos de 96 casos de tuberculosis se constaté una cicatriz BCG. Copyright © 1995 Published by Elsevier Ltd. https://doi.org/10.1016/0962-8479(95)90553-7. Vaccinul BCG a fost prima dată folosit în scop medical în anul 1921. The VDS was for some decades the Italian competitor of the French BCG vaccine against tuberculosis. The Italian anti-tubercular vaccine VDS was initially produced by the company Alfa Farmaceutici of Bologna of Dr Marino Golinelli. When Petragnani interrupted his studies and applications (because he was appointed in 1935 by Benito Mussolini, as Director General of Public Health), Professor Gaetano Salvioli continued his studies and applications. Injectarea se face cu o seringă de 0,5 sau 1 ml, prevăzută cu ac pentru inoculare intradermică. The VDS, definitively standardized between 1948 and 1953 by Professor Gaetano Salvioli, originated first in the studies and vaccine products of Professor Edoardo Maragliano (1849–1940) [1] and Professor Giovanni Petragnani (1893–1969), physiologist and rector of the University of Siena. [4], The composition and layout of the land Petragnani was as follows. Contacts of sputum-positive cases of tuberculosis had larger Mantoux responses. Reacția locală vaccinală se formează în 2-4 săptămâni sub forma unui nodul roșu –violaceu; nodulul se poate ulcera, formându-se o crustă care se elimina. Résultats: Sur 1050 sujets-contact de 96 cas tuberculeux, des cicatrices BCG ont été notées chez 76% des contacts. 18 others died from other causes.[8]. It was left, always in a bain-marie for about another 30 minutes. Salvioli's diffusing vaccine (known by its Italian initials VDS, for vaccino diffondente Salvioli) was an Italian vaccine against tuberculosis used from 1948 until 1976, formulated by professor Gaetano Salvioli (1894–1982) of the University of Bologna.The VDS was for some decades the Italian competitor of the French BCG vaccine against tuberculosis. Copyright © 2020 Elsevier B.V. or its licensors or contributors. Le vaccin BCG peut être administré le même jour qu’un autre vaccin vivant atténué injectable ou à au moins 4 semaines d’intervalle. 5 died but was verified by autopsies that it happened due to other causes. Design: Prospective cohort study of tuberculin sensitivity using the Mantoux technique (5 TU). Conclusion: Cette étude suggère que l'âge des contacts et le statut des frottis des malades sont des déterminants importants du degré de sensibilité tuberculinique. [3], Koch's bacilli were cultivated for 30–45 days in "Petragnani's ground". Les contacts avec des cas de tuberculose frottis positif ont montré des réponses plus importantes au test de Mantoux. This involuntary situation was studied after the war for about 10 years as an exceptional case. Conclusion: Este estudio sugiere que la edad de los contactos y el resultado de la baciloscopia de los casos índices constituyen determinantes importantes de la sensibilidad tuberculínica. Over the years there were several Italian centers (pediatric clinics, provincial consortia antitubercolari, headquarters of ONMI (Opera Nazionale Maternità Infanzia) that applied the "Italian-style vaccine" as they used to say at the time to distinguish it from the "French-style vaccine", the competitor BCG. Nu se aplică tratament local la nivelul reacției vaccinale. It was brought in bain-marie boiling and shaken everything until the ground had assumed a consistency of sticky type. Rezultate pentru {phrase} ({results_count} of {results_count_total}), Displaying {results_count} results of {results_count_total}, De exemplu: injectiapunctiamasurareadiabet, Administrarea transdermală a medicamentelor. Cadre: Clinique de la tuberculose, Hôpital St Vincent, Dublin. We filtered through sterile gauze in a graduated cylinder and we added to the filtrate 3% of glycerine and 4% of an aqueous solution to 2% of malachite. This batch caused an anomalous vaccination that involved, with a plague at the point of inoculation, 2797 schoolchildren from the province of Venice and infants of Ferrara and Trieste. ISM was, from 1894 to 1994, a non-profit institution entirely owned by the Municipality of Milan, with a plant in via Darwin in Milan. Results: In 1050 contacts of 96 cases of tuberculosis, BCG scars were noted in 76% of the contacts. – Acul trebuie să fie vizibil prin epidermă în timpul introducerii. It was cooled to about 40 degrees and added 4 eggs and a whole yolk. [7], Between 1938 and the first months of 1943 Professor Sandro Taronna (1901–1972), director of the Consortium Antitubercolare in Venice had vaccinated 354 children in the orphanage Pio Ospedale della Pietà of Venice. The bibliography of the time indicates that from 1948 to 1970 the VDS was applied very widely in different parts of Italy. In the summer of 1958, however, he gave up the production of the vaccine because its 6th supply of 3000 pieces, turned out not to correspond to the protocol provided by Professor Gaetano Salvioli. Se realizează tuturor nou-născuţilor cu greutatea mai mare de 2500 gr, începând din ziua 4-5 până la vârsta de 60 zile. [9] [6] Because of the bombing of the city, 132 children were transferred to the sanatorium building of Dolo in Venice, of which 54 were vaccinated with VPS. [10], The involuntary experiment of Dolo (Venice). La présence d'une cicatrice BCG ne semblait pas avoir une influence significative sur le degré de sensibilité tuberculinique. If Maragliano could boast, in 1903, at the World Congress of Medicine in Madrid that he was the first to develop an anti-tuberculosis serum with killed bacilli, Petragnani further developed his previous experiences and from 1927 to 1935 defined the Italian anti-tuberculosis vaccine under the name AIP (Anatubercolina Integrale Petragnani). In the area of Bologna (municipality and province) up to 80% of newborns were vaccinated. [6] Indicatii, contraindicatii, compozitie si produse naturale alternative. 1-7 zile de la naștere - vaccinul de tip Calmette Guerin BCG - este un vaccin administrat pentru a preveni tuberculoza. – seringă de 1ml cu ac intradermic, seringă 5 ml cu ac intramuscular – sterile By continuing you agree to the use of cookies. The killing of the bacterial suspensions was carried out with the exposure of the duration of few minutes to the heat under pressure at a temperature of 110°, but avoiding boiling. [2], One dose for newborns consisted of "a single intradermal injection, carried out at about half of the palmar face of the forearm, is used to introduce into the newborn baby a dose N of lyophilized anti-tuberculosis vaccine consisting of human Koch [bK] bacilli and cattle killed rapidly by heat. In 1970 it was declared that about 100,000 vaccinations had been performed with positive results. Indicatii: Nou-nascuti incepand de la varsta de 4 zile si copii intre 5 si 10 luni care nu prezinta cicatrice vaccinala sau prezinta o cicatrice vaccinala sub 3 mm. O reacţie normală după vaccinarea BCG, care demonstrează succesul vaccinării BCG, este induraţia la locul administrării urmată de o leziune locală care poate ulcera câteva săptămâni şi care se vindecă spontan în decurs de câteva luni, lăsând o cicatrice mai depigmentată şi uşor deprimată faţă de ţesutul inconjurator. – tampoane cu dezinfectant Manifestations cliniques après la vaccination. – Acul trebuie să fie aproape paralel cu suprafaţa pielii şi se introduce uşor cu bizoul în sus, aproximativ 2 mm în stratul superficial al dermului. Objective: To determine the influence of past BCG vaccination on tuberculin sensitivity in tuberculosis contacts. Conclusions: The study suggests that age of the contact and sputum status of the index case are important determinants of the degree of tuberculin sensitivity. Suspensia astfel obținută conține 0,10 mg bacili/ 0,1 ml și se utilizează cât mai curând ( dupa cel mult o oră ) fiind tot timpul protejată de lumina directă și de căldură. precum şi la copiii între 5 şi 10 luni, care nu prezintă cicatrice vaccinală sau prezintă o cicatrice vaccinală sub 3 mm, fără testare tuberculinică prealabilă. Método: Estudio prospectivo de cohortes sobre la sensibilidad tuberculínica utilizando la técnica de Mantoux (5 UT). Aspirăm de 2-3 ori lichidul în seringă pentru omogenizare. The presence of a BCG scar was not found to significantly influence the degree of tuberculin sensitivity. Bien que 97 % avaient une cicatrice visible de leur vaccination, 80 % se sont montrés anergiques a la tuberculine (0–1 mm). The bacterial patinas, or veils of the cultivated bacteria, were broken up and had to be pulverized, first with a spatula and then with mechanical stirrers to obtain a finer dispersion of the bacilli. In the two-year period 1956–1958 ISM produced six supplies. – O papulă (cu diametrul de 6-7 mm la nou-născut) în care foliculii piloşi sunt distinct vizibili reprezintă semnul unei injectări corecte. The degree of tuberculin sensitivity increased after 20 years and decreased after 60 years of age. It was then distributed in large tubes and it was coagulated at 80-85° for 30 minutes by means of a device designed by Petragnani himself, which provided for a thermoregulator and special large inclined tubes so that the soil solidified like a flute beak. From 1935 to 1948 Salvioli proceeded to the formulation of a vaccine called in that period VPS (vaccine Petragnani Salvioli). We use cookies to help provide and enhance our service and tailor content and ads. Vaccinarea BCG (Bacillus Calmette Guerin) este o vaccinare obligatorie în România, utilizată pentru imunizarea specifică împotriva tuberculozei. Acesta poate lăsa o cicatrice mică pe braț. Considering the excellent results and the spread that had the VDS, between 1956 and 1958 the ISM (Istituto Sieroterapico Milanese Serafino Belfanti) in Milan, then led by the Honorable Giovanni Battista Migliori, acquired the production rights from Alfa. Contact management guidelines may need to be reviewed and perhaps modified to reflect this finding. – fiola de vaccin şi solvent Vaccinarea BCG se realizează pe cale intradermică, cu vaccin pulbere liofilizată şi solvent. Papula dispare în aproximativ 30 de minute. – mănuşi de unică folosinţă. Se realizează tuturor nou-născuţilor cu greutatea mai mare de 2500 gr, începând din ziua 4-5 până la vârsta de 60 zile. La locul vaccinării rămâne o cicatrice denivelată fața de tegumentele din jur, la început de culoare violacee, apoi alb-sidefie cu diametrul de 5-6 mm și care constituie locul vaccinării. The ISM of Milan was the largest public company of serums and vaccines in Italy. It was widely applied in the municipality and province of Bologna, in particular at the pediatric clinic of the University of Bologna, directed by Professor Gaetano Salvioli himself. This dose [was] 0.68 mgr of human bK plus 0.07 mgr of bovine bK, to which [were] added 6 V units. In the Enter Domain section, enter the domain name.. From the control panel, click Create in the top right, then click Domains/DNS.. Ceux qui n'avaient pas de cicatrice n'ont eu aucune reponse au test. Results: In 1050 contacts of 96 cases of tuberculosis, BCG scars were noted in 76% of the contacts. Adenopatiile mai mari de 10-15 mm şi adenitele supurate sunt reacţiiexcepţionale şi sunt provocate în majoritatea cazurilor, de, IDR pozitiv, tuberculoză activă, imunodeficienţe congenitale, SIDA, boli febrile, convalescenţa dupa boli infecțioase, Afectiuni dermatologice acute, leucemii, limfoame, boli maligne. El grado de sensibilidad tuberculínica aumentaba después de los 20 años y disminuía después de los 60 años de edad. Afla si tu despre VACCIN BCG liofilizat pentru inoculare intradermica. of Jalovis [hyaluronidase] all in 0.2 cc of solvent [...]}". Creator and developer of the first anti-tuberculosis vaccination (the so-called "Maragliano Vaccine"), he was Senator of the Kingdom of Italy since 1900. Marco de referencia: Dispensario de tuberculosis, St Vincent's Hospital, Dublin. Attributing a ‘positive’ Mantoux response to past BCG vaccination may be encouraging a false sense of security in contacts recently exposed to an infectious case of tuberculosis. Approximativement 50%, 30% et 20% des contacts ont montré respectivement des réponses négatives (0 à 4 mm), positives (5 à 14 mm) et très positives (15+ mm) au test de Mantoux. Les directives sur la prise en charge des cas devraient être revues et éventuellement modifiées par la prise en compte de ces constatations. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Tuberculin sensitivity and the BCG scar in tuberculosis contacts. Setting: Tuberculosis clinic, St Vincents Hospital, Dublin. After a year of forced cohabitation because of the war, of the 54 vaccinated, 49 survived. Locul de injectare trebuie să fie curat şi uscat şi necontaminat cu substanţe antiseptice. II n'y avait pas de corrélation entre la dimension de la cicatrice et la réponse au Mantoux. Cicatricile vaccinale cu dimensiunea sub 3 mm dovedesc o vaccinare ineficientă. [5], In the second post-war period, the spread of TB in Italy was still very high, but antituberculous vaccination was not mandatory. One took 150 cubic centimeters of milk to which were added 1 gram of peptone, 6 grams of potato starch and a peeled potato washed and in pieces. Boli infecto-contagioase si nursing specific, Boli metabolice, de nutritie si nursing specific, Chirurgie generală și Nursing în Chirurgie generală, Endocrinologie si nursing in endocrinologie, Gastroenterologie și Nursing în Gastroenterologie, Nefrologie, Urologie si Nursing in Afectiuni Renale, Ortopedie, Traumatologie și Nursing specific, Puericultură, pediatrie și nursing specific, Îngrijirea stomelor (traheostomă, gastrostomă, colostomă, urostomă), Se trece la deschiderea fiolei de vaccin după ce îi înfăşurăm gâtul în foița de material plastic ce se găsește în ambalaj; deschiderea se face lent pentru a evita risipirea conținutului prin pătrunderea bruscă a aerului (ele fiind condiționate în vid), Cu seringa de 5 ml se aspiră 2 ml solvent și se trec în fiola de vaccin. Los contactos con casos de tuberculosis con baciloscopia positiva mostraron respuestas más importantes al test de Mantoux. Objet: Déterminer l'influence d'une vaccination antérieure par le BCG sur la sensibilité tuberculinique chez des personnes en contact avec des tuberculeux. Read about scars, including the different types, how and where they form and how they're treated. Edoardo Maragliano (Genoa, 1 June 1849 - Genoa, 10 March 1940) was an Italian doctor and clinician. Aproximadamente el 50%, 30% y 20% de los contactos mostraron respuestas al test de Mantoux negativas (0–4 mm), positivas (5–14 mm) y fuertemente positivas (15+ mm), respectivamente. Of the 78 unvaccinated, 48 survived but 12 died due to Tuberculosis. Estos hallazgos podrían llevar quizás a una revision de las directivas para el manejo de los contactos. – Injecţia se administrează lent. From 1959, until the decision of the Ministry of Health to officially adopt the BCG in Italy (art.1 of the Ministerial Decree of 25 June 1976), the production of VDS returned to the companies of Dr. Marino Golinelli. In the province of Venice, the Consortium Antitubercolare Provincial vaccinated between 1953 and 1958 about 16 000 people, especially primary school children. Objetivo: Determinar la influencía de una vacunación BCG previa sobre la sensibilidad tuberculímíca en contactos de tuberculosis. – Locul injectării este bine să se lase descoperit pentru a se facilita vindecarea. Nu se aplică tratament local la nivelul reacției vaccinale. Acesta se află pe lista de medicamente esențiale a Organizației Mondiale a Sănătății a celei mai importante medicații necesare într-un sistem de sănătate de bază. Atribuir una respuesta positiva al test de Mantoux a una vacunación BCG previa puede provocar una falsa impresión de inmunidad en los contactos recientemente expuestos a casos contagiosos de tuberculosis. Voir Manifestations cliniques, Présentation des manifestations cliniques. Unfortunately, tuberculosis also entered into the sanatorium, causing several victims. Schéma: Etude prospective de cohortes sur la sensibilité tuberculinique utilisant la technique de Mantoux (5TU). Minerva Medica (rivista ) vol.
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